pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine

{
  "id": "MLC-T-ONC-016296",
  "term": "pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA vaccine containing mammalian expression vector pUMVC3, encoding epitopes of human insulin-like growth factor-binding protein 2 (hIGFBP-2) with potential immunostimulating and antineoplastic activities. Upon vaccination, pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine may activate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against hIGFBP-2-expressing cells. The tumor associated antigen (TAA) hIGFBP-2, a member of the insulin like growth factor receptor family, is overexpressed in a number of cancer cell types and its expression has been associated with increased invasiveness.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pumvc3-higfbp-2-multi-epitope-plasmid-dna-vaccine/"
}