pUMVC3-IGFBP2-HER2-IGF1R plasmid DNA vaccine

{
  "id": "MLC-T-ONC-016297",
  "term": "pUMVC3-IGFBP2-HER2-IGF1R plasmid DNA vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A polyepitope plasmid DNA vaccine containing the mammalian expression vector pUMVC3 encoding epitopes derived from three tumor-associated antigens (TAAs): human insulin-like growth factor-binding protein 2 (IGFBP2), human epidermal growth factor receptor 2 (HER2; ERBB2) and insulin-like growth factor 1 receptor (IGF1R), with potential immunostimulating and antineoplastic activities. Upon intradermal vaccination, pUMVC3-IGFBP2-HER2-IGF1R plasmid DNA vaccine transfects local keratinocytes, which process the plasmid, express the epitopes and present them to antigen-presenting cells (APCs). This activates the immune system to mount a combined response from specific T helper type 1 (Th1) cells, memory T cells and cytotoxic T lymphocytes (CTL) against IGFBP2-, HER2-, and IGF1R-expressing tumor cells. IGFBP2, HER2, and IGF1R are tumor-associated proteins overexpressed in certain tumor cell types, and play key roles in cellular proliferation and survival.",
  "synonyms": [
    "WOKVAC",
    "pUMVC3-IGFBP2-HER2-IGF1R vaccine",
    "pUMVC3-IGFBP2-HER2-IGF1R",
    "WOKVAC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pumvc3-igfbp2-her2-igf1r-plasmid-dna-vaccine/"
}