HER2 ECD+TM virus-like replicon particles vaccine AVX901

{
  "id": "MLC-T-ONC-014088",
  "term": "HER2 ECD+TM virus-like replicon particles vaccine AVX901",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine based on virus-like replicon particles (VRP) packaged with an alphaviral vector encoding the extracellular domain (ECD) and transmembrane (TM) regions of the human epidermal growth factor receptor 2 (EGFR2, NEU or HER2), with potential antineoplastic activity. After immunization with HER2 ECD+TM virus-like replicon particles vaccine AVX901, the VRPs infect cells and express HER2 ECD+TM protein that may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. The alphaviral replicon of this vaccine is an attenuated strain of the Venezuelan equine encephalitis virus (VEEV) in which 3 of the 7 viral genes were substituted with a truncated HER2 gene to create a self-amplifying replicon RNA. HER2, a tyrosine kinase involved in several cell growth signaling pathways, is dysregulated or overexpressed in a wide variety of cancer cell types.",
  "synonyms": [
    "VRP-HER2 ECDTM",
    "HER2 ECDTM VRP",
    "alphavirus-like replicon particles-containing self-amplifying replicon RNA for HER2 AVX901",
    "VRP-HER2 AVX901"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her2-ecd-plus-tm-virus-like-replicon-particles-vaccine-avx901/"
}