HER2/neu peptide vaccine GLSI-100

{
  "id": "MLC-T-ONC-014101",
  "term": "HER2/neu peptide vaccine GLSI-100",
  "field": "Oncology and biomedicine",
  "definition": "A cancer peptide vaccine comprised of the epitope GP2, a nine amino acid peptide (amino acids 654-662) derived from the tumor-associated antigen (TAA) HER2/neu (ErbB-2) and the immune-adjuvant granulocyte macrophage-colony-stimulating factor (GM-CSF), with potential immunomodulating and antineoplastic activities. Upon intradermal administration of the HER2/neu peptide vaccine GLSI-100, GP2 may induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing the HER2/neu antigen, which may result in the inhibition of proliferation of HER2/neu-expressing tumor cells. HER2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumor cell types. GM-CSF enhances the CTL-mediated immune response against HER2/neu.",
  "synonyms": [
    "HER2/neu peptide GP2/GM-CSF GLSI-100",
    "GP2 peptide/GM-CSF GLSI-100",
    "peptide vaccine GLSI-100"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her2-neu-peptide-vaccine-glsi-100/"
}