HLA-A1, A2, B35-restricted survivin peptides/Montanide ISA-51 vaccine

{
  "id": "MLC-T-ONC-014134",
  "term": "HLA-A1, A2, B35-restricted survivin peptides/Montanide ISA-51 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide vaccine comprised of synthetic HLA-A1, -A2 and -B35 restricted survivin epitopes combined with the adjuvant Montanide ISA-51 with potential antineoplastic activity. Upon administration, HLA-A1, A2, B35-restricted survivin peptides/Montanide ISA-51 vaccine may stimulate a cytotoxic T cell response against tumor cells that overexpress survivin, resulting in tumor cell lysis. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.",
  "abbreviation": "SRV PEP VAC",
  "synonyms": [
    "survivin peptide vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hla-a1-a2-b35-restricted-survivin-peptides-montanide-isa-51-vaccine/"
}