HLA-A2, A3-restricted FGF-5 peptides/Montanide ISA-51 vaccine

{
  "id": "MLC-T-ONC-014136",
  "term": "HLA-A2, A3-restricted FGF-5 peptides/Montanide ISA-51 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide vaccine comprised of synthetic HLA-A2- and HLA-A3-binding peptides, derived from amino acid sequences of fibroblast growth factor-5 (FGF-5), combined with the adjuvant Montanide ISA-51 with potential antineoplastic activity. HLA-A2, A3-restricted FGF-5 peptides contain motifs recognized by the MHC class I molecules HLA-A2 and HLA-A3 and may stimulate a cytotoxic T-cell response against tumor cells that overexpress FGF-5. Montanide ISA-51 (also known as incomplete Freund's adjuvant or IFA), a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated immune responses to antigens.",
  "abbreviation": "HLA-A2A3-FGF5-ISA51",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hla-a2-a3-restricted-fgf-5-peptides-montanide-isa-51-vaccine/"
}