iodine I 124 18B10(10L)

{
  "id": "MLC-T-ONC-014501",
  "term": "iodine I 124 18B10(10L)",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), and conjugated with the radioisotope iodine I 124, that can potentially be used as an imaging agent for positron emission tomography (PET)/computed tomography (CT). Upon administration, the antibody moiety of iodine I 124 18B10(10L) selectively targets and binds to CLDN18.2. The CLDN18.2-expressing tumor cells can then be visualized using PET/CT. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "[124I]-18B10(10L)",
    "124I-18B10(10L)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-124-18b10-10l/"
}