iPSC-derived natural killer cells FT500

{
  "id": "MLC-T-ONC-014565",
  "term": "iPSC-derived natural killer cells FT500",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of off-the-shelf, natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived natural killer cells FT500 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, iPSC-NK cells secrete inflammatory cytokines and chemokines including interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokines 3, 4, and 22 (CCL3, CCL4, and CCL22), and C-X-C motif chemokine 10 (CXCL10), thereby enhancing T-cell activity and recruitment to the tumor site.",
  "synonyms": [
    "induced pluripotent stem cell-derived natural killer cells FT500",
    "iPSC-derived NK cells FT500",
    "iPSC-NK cells FT500"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ipsc-derived-natural-killer-cells-ft500/"
}