Isotretinoin

{
  "id": "MLC-T-ONC-004547",
  "term": "Isotretinoin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug closely related to vitamin A that is used to treat severe acne and may also be used to treat other skin conditions and some types of cancer, including neuroblastoma. It is also being studied in the prevention and treatment of other types of cancer. Isotretinoin binds to and activates certain protein receptors in cells, including cancer cells. This may slow the growth of cancer cells and change how these cells look and act. Isotretinoin is a type of retinoid. Also called 13-cis retinoic acid.",
    "A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization."
  ],
  "abbreviation": "13-CRA",
  "synonyms": [
    "13-cis retinoic acid",
    "13-cis-retinoic acid",
    "13-cis-vitamin A acid",
    "cis-retinoic acid",
    "isotretinoinum",
    "Neovitamin A Acid",
    "neovitamin A"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/isotretinoin/"
}