ixabepilone

{
  "id": "MLC-T-ONC-004564",
  "term": "ixabepilone",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with capecitabine to treat breast cancer that is locally advanced or has spread to other parts of the body and did not get better after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixabepilone blocks cell growth by stopping cell division and may kill cancer cells. It is a type of epothilone analog and a type of antimicrotubule agent. Also called BMS-247550 and Ixempra.",
    "An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines."
  ],
  "synonyms": [
    "BMS-247550",
    "Ixempra",
    "epothilone B lactam",
    "azaepothilone B",
    "epothilone-B BMS 247550",
    "epothilone"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ixabepilone/"
}