Leuprolide mesylate

{
  "id": "MLC-T-ONC-004802",
  "term": "Leuprolide mesylate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with advanced prostate cancer. Leuprolide mesylate initially causes the pituitary gland to make more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), temporarily increasing testosterone levels in men. With continued use, leuprolide mesylate lowers the amount of LH and FSH the pituitary gland releases, leading to a drop in testosterone levels. Leuprolide mesylate may stop the growth of cancer cells that need testosterone to grow. It is a type of hormone therapy called a luteinizing hormone-releasing hormone (LHRH) agonist. Also called Camcevi.",
    "The mesylate salt form of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In males, this results in a significant decline in testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression."
  ],
  "synonyms": [
    "Camcevi"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/leuprolide-mesylate/"
}