liposome-encapsulated RB94 plasmid DNA gene therapy agent SGT-94

{
  "id": "MLC-T-ONC-014839",
  "term": "liposome-encapsulated RB94 plasmid DNA gene therapy agent SGT-94",
  "field": "Oncology and biomedicine",
  "definition": "A systemic gene therapy anti-cancer agent composed of cationic liposomes, which encapsulates plasmid DNA encoding for the tumor suppressor gene RB94 and is complexed with anti-transferrin receptor single chain antibody fragment (TfRscFv), with potential antineoplastic activity. Upon systemic administration of liposome-encapsulated RB94 plasmid DNA gene therapy agent SGT-94, the TfRscFv portion of this agent selectively targets the tumor cells expressing transferrin receptors. TfRscFv binding to the transferrin receptor allows receptor-mediated endocytosis and transfection, followed by the expression of RB94 gene. This induces tumor cell apoptosis through an as-of-yet unknown pathway. RB94 is a modified, N-terminal truncated form of the full-length protein retinoblastoma gene RB110, and exerts enhanced antitumor activity. The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin, and is overexpressed in a variety of tumor types.",
  "synonyms": [
    "TfRscFv/Lip/RB94"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposome-encapsulated-rb94-plasmid-dna-gene-therapy-agent-sgt-94/"
}