lixumista acetate

{
  "id": "MLC-T-ONC-014858",
  "term": "lixumista acetate",
  "field": "Oncology and biomedicine",
  "definition": "The acetate salt form of lixumistat, an orally bioavailable biguanide compound and mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity. Upon administration, lixumistat inhibits oxidative phosphorylation, decreases mitochondrial function, prevents tumor cell metabolism and deprives tumor cells of energy, thereby preventing tumor cell proliferation. Mitochondrial OxPhos is overactivated in cancer cells and plays a key role in tumor cell proliferation. Drug resistant tumor cells are very susceptible to decreased mitochondrial OxPhos as they cannot easily compensate for the decrease in mitochondrial function by increasing glycolysis.",
  "synonyms": [
    "mitochondrial oxidative phosphorylation inhibitor IM156",
    "OxPhos inhibitor IM156",
    "HL271 acetate",
    "oxidative phosphorylation inhibitor IM156"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lixumista-acetate/"
}