Loperamide hydrochloride

{
  "id": "MLC-T-ONC-004928",
  "term": "Loperamide hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat diarrhea. Loperamide hydrochloride works by binding to mu opioid receptors in the intestines, which slows the movement of the muscles in the intestines. This gives the body more time to absorb water and electrolytes from the feces (waste matter), resulting in firmer and less frequent bowel movements. Loperamide hydrochloride is a type of synthetic opioid agonist that works only in the gut when used as directed. Also called Imodium.",
    "The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects."
  ],
  "synonyms": [
    "Imodium"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/loperamide-hydrochloride/"
}