lutetium Lu 177 PSMA-EB-01

{
  "id": "MLC-T-ONC-014923",
  "term": "lutetium Lu 177 PSMA-EB-01",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of PSMA-EB-01, a human prostate-specific membrane antigen (PSMA)-targeting ligand conjugated to the Evans blue (EB) moiety, and linked to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 PSMA-EB-01, PSMA-EB-01 targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. The EB moiety of PSMA-EB-01 binds to serum albumin, which extends its circulation half-life. This may improve tumor uptake and efficacy of the agent.",
  "synonyms": [
    "177Lu-PSMA-EB-01",
    "lutetium Lu 177-labeled PSMA-EB-01",
    "lutetium Lu 177-LNC1003",
    "[177Lu]Lu-LNC1003"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lutetium-lu-177-psma-eb-01/"
}