LV.IL-2/B7.1-transduced AML blast vaccine

{
  "id": "MLC-T-ONC-014943",
  "term": "LV.IL-2/B7.1-transduced AML blast vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A whole-cell cancer vaccine, containing human acute myeloid leukemic (AML) blasts that have been genetically engineered to express a B7.1/IIL-2 fusion protein encoded by a self-inactivating lentiviral vector (LV), with potential antineoplastic and immunomodulating activities. Upon administration, LV.IL-2/B7.1-transduced AML blast vaccine may stimulate a host cytotoxic T lymphocyte (CTL) response against AML cells. The single fusion protein encoded by the LV is postsynthetically cleaved to produce biologically active membrane-anchored B7.1 and secreted IL-2 in AML blasts; combined expression of IL-2 and the co-stimulatory molecule B7.1 by AML blasts may increase stimulation of both allogeneic and autologous cytotoxic T cells.",
  "synonyms": [
    "lentivirus-transduced AML blasts expressing B7.1 and IL-2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lv-il-2-b7-1-transduced-aml-blast-vaccine/"
}