lyso-thermosensitive liposomal doxorubicin

{
  "id": "MLC-T-ONC-014953",
  "term": "lyso-thermosensitive liposomal doxorubicin",
  "field": "Oncology and biomedicine",
  "definition": "A temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Upon intravenous administration, circulating thermosensitive liposomes are activated locally by increasing the tumor temperature to 40-41 degrees Celsius using an external heat source. The elevated temperature causes compositional changes in the liposomes, creating openings that allow for the release of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing normal tissues unexposed to heat treatment.",
  "synonyms": [
    "heat-activated liposomal doxorubicin hydrochloride",
    "lyso-thermosensitive liposome doxorubicin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lyso-thermosensitive-liposomal-doxorubicin/"
}