m-azidopyrimethamine

{
  "id": "MLC-T-ONC-015029",
  "term": "m-azidopyrimethamine",
  "field": "Oncology and biomedicine",
  "definition": "An antifolate derived from diaminopyrimidine with cytotoxic properties. With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX.",
  "abbreviation": "MZP",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/m-azidopyrimethamine/"
}