Aminopterin

{
  "id": "MLC-T-ONC-000457",
  "term": "Aminopterin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that belongs to the family of drugs called antimetabolites.",
    "A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis."
  ],
  "abbreviation": "APGA",
  "synonyms": [
    "4-aminofolic acid",
    "4-aminopteroylglutamic acid",
    "4-aminopteroyl-glutamic Acid",
    "aminopteroylglutamic acid",
    "4-amino-PGA"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aminopterin/"
}