Mapatumumab

{
  "id": "MLC-T-ONC-005131",
  "term": "Mapatumumab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill the tumor cells. Mapatumumab is a type of monoclonal antibody. Also called anti-TRAIL R1-mAb and HGS-ETR1.",
    "A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth."
  ],
  "abbreviation": "TRM-1 mAb",
  "synonyms": [
    "anti-TRAIL R1-mAb",
    "HGS-ETR1",
    "Anti-TRAIL R1-mAb"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mapatumumab/"
}