melphalan hydrochloride/sulfobutyl ether beta-cyclodextrin complex

{
  "id": "MLC-T-ONC-015084",
  "term": "melphalan hydrochloride/sulfobutyl ether beta-cyclodextrin complex",
  "field": "Oncology and biomedicine",
  "definition": "A propylene glycol-free intravenous formulation containing the hydrochloride salt of the nitrogen mustard phenylalanine derivative melphalan complexed with polyanionic sulfobutyl ether beta-cyclodextrin (SBE-CD) with potential antineoplastic activity. Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA; RNA and proteins may also be alkylated. Subsequently, RNA transcription and protein synthesis are inhibited, resulting in cell growth arrest. The addition of sulfobutyl ether beta-cyclodextrin to the formulation improves the solubility, stability and ease of use of melphalan; cyclodextrins are cyclic dextrins derived from starch.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/melphalan-hydrochloride-sulfobutyl-ether-beta-cyclodextrin-complex/"
}