Methylnaltrexone

{
  "id": "MLC-T-ONC-015138",
  "term": "Methylnaltrexone",
  "field": "Oncology and biomedicine",
  "definition": "A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.",
  "abbreviation": "MNTX",
  "synonyms": [
    "N-methylnaltrexone bromide",
    "quaternary ammonium naltrexone"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/methylnaltrexone/"
}