mitosis-angiogenesis inhibitor R1530

{
  "id": "MLC-T-ONC-015208",
  "term": "mitosis-angiogenesis inhibitor R1530",
  "field": "Oncology and biomedicine",
  "definition": "A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta‚ FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.",
  "abbreviation": "MAI R1530",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mitosis-angiogenesis-inhibitor-r1530/"
}