Mitotane

{
  "id": "MLC-T-ONC-005420",
  "term": "Mitotane",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing disease).",
    "A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production."
  ],
  "abbreviation": "DDD",
  "synonyms": [
    "o,p'-DDD",
    "Chloditan",
    "Chlodithane",
    "Khloditan",
    "Mytotan",
    "Ortho,para-DDD"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mitotane/"
}