modified vitamin D binding protein macrophage activator EF-022

{
  "id": "MLC-T-ONC-015230",
  "term": "modified vitamin D binding protein macrophage activator EF-022",
  "field": "Oncology and biomedicine",
  "definition": "A modified version of vitamin D binding protein (VDBP; Gc protein) macrophage activator, with potential antineoplastic and anti-angiogenic activities. Upon administration, modified VDBP-macrophage activator EF-022, acting in a similar manner as VDBP-macrophage activating factor (GcMAF), is able to activate tumoricidal macrophages, thereby enhancing the killing and eradication of cancer cells. In addition, EF-022 may inhibit tumor cell proliferation, migration and angiogenesis. VDBP is a glycoprotein and precursor for macrophage activating factor (MAF), which promotes macrophage activation; however VDBP can be deglycosylated by serum alpha-N-acetylgalactosaminidase, which is secreted from cancerous cells, and cannot be converted to MAF. Thus, the macrophage activation cascade is often impaired in tumor cells and plays a key role in tumor immunosuppression. Modification of VDBP stabilizes MAF.",
  "synonyms": [
    "MVDP-macrophage activator",
    "modified VDBP-macrophage activator EF-022"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/modified-vitamin-d-binding-protein-macrophage-activator-ef-022/"
}