Mps1 inhibitor BOS172722

{
  "id": "MLC-T-ONC-015299",
  "term": "Mps1 inhibitor BOS172722",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, selective inhibitor of the serine/threonine-protein kinase monopolar spindle 1 (Mps1; TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BOS172722 binds to and inhibits the activity of Mps1, a core component of the spindle assembly checkpoint (SAC). Inhibition of Mps1 activity compromises spindle assembly checkpoint, increases chromosome missegregation errors and decreases cancer cell viability. Mps1, a dual-specificity protein kinase expressed in proliferating normal tissues and aberrantly overexpressed in certain tumor types, is activated during mitosis and is essential in proper SAC function and chromosomal alignment.",
  "synonyms": [
    "TTK inhibitor BOS172722",
    "monopolar spindle 1 inhibitor BOS172722"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mps1-inhibitor-bos172722/"
}