Multi-kinase inhibitor ST-1898

{
  "id": "MLC-T-ONC-015354",
  "term": "Multi-kinase inhibitor ST-1898",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule inhibitor of multiple receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, multi-kinase inhibitor ST-1898 inhibits the activity of multiple RTKs, which may include vascular endothelial growth factor receptor 2 (VEGFR-2; VEGFR2), hepatocyte growth factor receptor (HGFR; c-Met), AXL (UFO), platelet-derived growth factor receptor alpha (PDGFRa), rearranged during transfection (RET) and mast/stem cell factor receptor c-Kit (SCFR; CD117). This may result in antitumor activity in tumor cells in which these RTKs are upregulated or dysregulated.",
  "synonyms": [
    "multi-target tyrosine kinase inhibitor ST-1898"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/multi-kinase-inhibitor-st-1898/"
}