multitargeted tyrosine kinase inhibitor JNJ-26483327

{
  "id": "MLC-T-ONC-015361",
  "term": "multitargeted tyrosine kinase inhibitor JNJ-26483327",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/multitargeted-tyrosine-kinase-inhibitor-jnj-26483327/"
}