Nabilone

{
  "id": "MLC-T-ONC-005648",
  "term": "Nabilone",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A synthetic pill form of an active chemical in marijuana called delta-9-tetrahydrocannabinol (THC). Nabilone is used to treat nausea and vomiting caused by chemotherapy in patients who have not been helped by other therapy. It is a type of cannabinoid. Also called Cesamet.",
    "A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea."
  ],
  "synonyms": [
    "Cesamet",
    "Cpd 109514"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nabilone/"
}