nanoparticle SN-38-encapsulated micelle formulation IT-141

{
  "id": "MLC-T-ONC-015425",
  "term": "nanoparticle SN-38-encapsulated micelle formulation IT-141",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle-based formulation consisting of polymeric micelles, composed of triblock copolymers, loaded with the bioactive hydrophobic irinotecan metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38), with potential antineoplastic activity. Upon administration, nanoparticle SN-38-encapsulated micelle formulation IT141 diffuses into the tumor site and the SN-38 moiety binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, which results in DNA breaks, inhibition of DNA replication, and apoptosis. Compared to SN-38 alone, this formulation increases the water solubility of SN-38 and allows the delivery of higher doses of SN-38. IT-141 also has a much longer circulation time and reduces toxicity to normal, healthy tissues.",
  "synonyms": [
    "nanoparticle SN-38 formulation IT141"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanoparticle-sn-38-encapsulated-micelle-formulation-it-141/"
}