Nanoparticle SN-38-encapsulated micelle formulation SNB-101

{
  "id": "MLC-T-ONC-015426",
  "term": "Nanoparticle SN-38-encapsulated micelle formulation SNB-101",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle-based formulation consisting of double core-shell (DUCS) micelles containing 7-ethyl-10-hydroxy-camptothecin (SN-38), the active, hydrophobic metabolite of the prodrug irinotecan, with potential antineoplastic activity. Upon intravenous administration, nanoparticle SN-38-encapsulated micelle formulation SNB-101 diffuses into the tumor site and the SN-38 moiety binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, which results in DNA breaks, inhibition of DNA replication, and apoptosis. Compared to SN-38 alone, this formulation increases the water solubility of the poorly soluble drug SN-38, and due to the stability of this formulation, it has a much longer circulation time and reduces toxicity to normal, healthy tissues.",
  "synonyms": [
    "nanoparticle formulation SNB-101",
    "SN-38-containing nano-sized micelle formulation SNB-101",
    "SN-38-containing nano-particle SNB-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanoparticle-sn-38-encapsulated-micelle-formulation-snb-101/"
}