Nelarabine

{
  "id": "MLC-T-ONC-005724",
  "term": "Nelarabine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults and children aged 1 year and older with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. It is used in patients whose cancer has not gotten better or has recurred (come back) after treatment with other anticancer drugs. Nelarabine stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. Also called 506U78 and Arranon.",
    "An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells."
  ],
  "synonyms": [
    "506U78",
    "Arranon"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nelarabine/"
}