next-generation sequencing

{
  "id": "MLC-T-ONC-005804",
  "term": "next-generation sequencing",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A term that describes methods used in the lab to learn the order of building blocks (called nucleotides) for millions of DNA or RNA fragments at the same time. Computers are used to piece together the fragments in order to sequence a person or other organism’s entire DNA, large segments of DNA or RNA, or the DNA in specific types of cells from a sample of tissue. Next-generation sequencing can also identify changes in certain areas of the genome or in specific genes. There are many different types of next-generation sequencing methods, including whole-genome sequencing, whole-exome sequencing, multigene panel testing, and transcriptome sequencing. Next-generation sequencing may help researchers understand the cause of certain diseases, such as cancer. Also called massively parallel sequencing and NGS.",
    "A high-throughput method used to determine a portion of the nucleotide sequence of an individual’s genome. This technique utilizes DNA sequencing technologies that are capable of processing multiple DNA sequences in parallel. Also called massively parallel sequencing and NGS."
  ],
  "synonyms": [
    "massively parallel sequencing",
    "NGS"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/next-generation-sequencing/"
}