NFE2L2/KEAP1/CUL3 mutant-targeting agent MGY825

{
  "id": "MLC-T-ONC-015499",
  "term": "NFE2L2/KEAP1/CUL3 mutant-targeting agent MGY825",
  "field": "Oncology and biomedicine",
  "definition": "An antineoplastic agent targeting mutant forms of nuclear factor erythroid 2-related factor 2 protein (NFE2L2), Kelch-like ECH-associated protein 1 (KEAP1), and Cullin-3 (CUL3), with potential antineoplastic activity. Upon administration, NFE2L2/KEAP1/CUL3 mutant-targeting agent MGY825 inhibits the activity of NFE2L2, KEAP1 and CUL3 mutant forms, thereby halting the proliferation of NFE2L2, KEAP1, and CUL3 mutant-expressing tumor cells. NFE2L2/KEAP1/CUL3 are mutated in certain tumor cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nfe2l2-keap1-cul3-mutant-targeting-agent-mgy825/"
}