Nucleoside analog DFP-10917

{
  "id": "MLC-T-ONC-015550",
  "term": "Nucleoside analog DFP-10917",
  "field": "Oncology and biomedicine",
  "definition": "A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form, which functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.",
  "synonyms": [
    "CNDAC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nucleoside-analog-dfp-10917/"
}