O6-benzylguanine

{
  "id": "MLC-T-ONC-015577",
  "term": "O6-benzylguanine",
  "field": "Oncology and biomedicine",
  "definition": "A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA.",
  "abbreviation": "BG",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/o6-benzylguanine/"
}