OSI-7904L

{
  "id": "MLC-T-ONC-006165",
  "term": "OSI-7904L",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.",
    "A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904."
  ],
  "expansions": [
    "OSI-7904 liposomal"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/osi-7904l/"
}