p53/HDM2 interaction inhibitor CGM097

{
  "id": "MLC-T-ONC-015753",
  "term": "p53/HDM2 interaction inhibitor CGM097",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.",
  "synonyms": [
    "HDM2/p53 inhibitor CGM097"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p53-hdm2-interaction-inhibitor-cgm097/"
}