p53-HDM2 protein-protein interaction inhibitor MI-773

{
  "id": "MLC-T-ONC-015754",
  "term": "p53-HDM2 protein-protein interaction inhibitor MI-773",
  "field": "Oncology and biomedicine",
  "definition": "An orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, the p53-HDM2 protein-protein interaction inhibitor MI-773 binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival.",
  "synonyms": [
    "p53-MDM2 interaction inhibitor MI-773"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p53-hdm2-protein-protein-interaction-inhibitor-mi-773/"
}