PAK4 inhibitor PF-03758309

{
  "id": "MLC-T-ONC-015772",
  "term": "PAK4 inhibitor PF-03758309",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.",
  "synonyms": [
    "p21-activated kinase 4 inhibitor PF-03758309"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pak4-inhibitor-pf-03758309/"
}