palifermin

{
  "id": "MLC-T-ONC-006263",
  "term": "palifermin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to prevent and treat severe oral mucositis (mouth sores). It is used in patients with blood cancer who are being treated with high-dose chemotherapy and radiation therapy followed by an autologous stem cell transplant. It is also being studied in the prevention and treatment of common side effects in other types of cancer. Palifermin is a form of human keratinocyte growth factor that is made in the laboratory. It binds to certain receptors on the surface of cells in the lining of the mouth, stomach, and intestines. This may help protect healthy tissue from some of the side effects caused by certain types of cancer treatment. Palifermin is a type of cytoprotective agent. Also called Kepivance.",
    "A recombinant form of the endogenous human keratinocyte growth factor. Palifermin binds to epithelial cell surface receptors in the lining of the mouth and gastrointestinal tract, resulting in stimulation of epithelial cell proliferation, differentiation and upregulation of cytoprotective mechanisms."
  ],
  "abbreviation": "rhKGF",
  "synonyms": [
    "Kepivance",
    "recombinant human keratinocyte growth factor",
    "growth factor, recombinant human keratinocyte",
    "keratinocyte growth factor, recombinant human",
    "rhu keratinocyte growth factor"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/palifermin/"
}