Para-toluenesulfonamide

{
  "id": "MLC-T-ONC-015829",
  "term": "Para-toluenesulfonamide",
  "field": "Oncology and biomedicine",
  "definition": "A low-molecular-weight organic compound with potential antineoplastic activity. Upon intra-tumoral injection, para-toluenesulfonamide increases lysosomal membrane permeabilization (LMP) and the release of cathepsin B. Cytosolic cathepsin B released from lysosomes cleaves and activates proapoptotic B-cell lymphoma 2 (Bcl-2) family member BH3 interacting-domain death agonist (Bid) and poly [ADP-ribose] polymerase 1 (PARP-1), which may induce tumor cell death.",
  "abbreviation": "PTS",
  "synonyms": [
    "p-toluenesulfonamide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/para-toluenesulfonamide/"
}