pegfilgrastim

{
  "id": "MLC-T-ONC-006448",
  "term": "pegfilgrastim",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that is a form of filgrastim and is used to prevent infection in adults and children with neutropenia (a lower-than-normal number of white blood cells) caused by some types of chemotherapy. Pegfilgrastim helps the bone marrow make more white blood cells and is able to stay in the body longer than filgrastim, so it doesn't need to be given as often. It is a type of colony-stimulating factor. Also called filgrastim-SD/01, Fulphila, Neulasta, Nyvepria, Udenyca, and Ziextenzo.",
    "A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life."
  ],
  "synonyms": [
    "filgrastim-SD/01",
    "Fulphila",
    "Neulasta",
    "Nyvepria",
    "Udenyca",
    "Ziextenzo",
    "pegfilgrastim biosimilar PF-06881894",
    "pegfilgrastim-cbqv",
    "pegfilgrastim biosimilar Nyvepria",
    "pegfilgrastim-apgf",
    "filgrastim SD-01",
    "pegfilgrastim-bmez",
    "pegfilgrastim biosimilar Pegcyte",
    "pegfilgrastim biosimilar HSP-130",
    "pegfilgrastim-jmdb",
    "pegfilgrastim biosimilar Udenyca",
    "SD-01 sustained duration G-CSF",
    "SD-01",
    "pegfilgrastim biosimilar Ziextenzo",
    "pegylated G-CSF",
    "pegylated GCSF",
    "pegylated granulocyte colony stimulating factor",
    "tripegfilgrastim"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pegfilgrastim/"
}