pegfilgrastim anti-neutropenic factor

{
  "id": "MLC-T-ONC-015907",
  "term": "pegfilgrastim anti-neutropenic factor",
  "field": "Oncology and biomedicine",
  "definition": "A long-acting, engineered and pegylated version of human granulocyte-colony stimulating factor (G-CSF), with potential hematopoietic activity. Similar to G-CSF, pegfilgrastim anti-neutropenic factor (ANF) binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, the conjugation with a branched polyethylene glycol molecule reduces renal clearance and increases its plasma half-life.",
  "synonyms": [
    "PEG G-CSF ANF",
    "pegfilgrastim ANF"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pegfilgrastim-anti-neutropenic-factor/"
}