pegylated granulocyte colony stimulating factor MAXY-G34

{
  "id": "MLC-T-ONC-015922",
  "term": "pegylated granulocyte colony stimulating factor MAXY-G34",
  "field": "Oncology and biomedicine",
  "definition": "A long-acting, pegylated recombinant variant of human granulocyte colony-stimulating factor (G-CSF) with immunomodulating activity. Pegylated granulocyte colony stimulating factor MAXY-G34 contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as pegylation sites; other naturally occurring lysine residues have been removed to prevent pegylation and the variant G-CSF is pegylated with methoxypolyethylene glycol succinimidyl propionate (mPEG SPA) at three amino acid residues. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. A difference in the degree of pegylation may account for the extended half-life of this agent compared to pegfilgrastim which is pegylated at only one amino acid residue.",
  "abbreviation": "PEG-CSF MAXY-G34",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pegylated-granulocyte-colony-stimulating-factor-maxy-g34/"
}