phosphorodiamidate morpholino oligomer AVI-4126

{
  "id": "MLC-T-ONC-016014",
  "term": "phosphorodiamidate morpholino oligomer AVI-4126",
  "field": "Oncology and biomedicine",
  "definition": "A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.",
  "abbreviation": "PMO AVI-4126",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/phosphorodiamidate-morpholino-oligomer-avi-4126/"
}