PI3K inhibitor TL117

{
  "id": "MLC-T-ONC-016032",
  "term": "PI3K inhibitor TL117",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor, with potential antineoplastic activity. Upon oral administration, PI3K inhibitor TL117 specifically inhibits the activity of PI3K, and prevents the activation of the PI3K/Akt (protein kinase B)-mediated signaling pathway. This may result in the inhibition of both tumor cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pi3k-inhibitor-tl117/"
}