pooled mutant KRAS-targeted long peptide vaccine

{
  "id": "MLC-T-ONC-016181",
  "term": "pooled mutant KRAS-targeted long peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide vaccine containing a mixture of long peptides that are derived from tumor-specific mutant forms of the KRAS (K-ras) antigen, with potential immunostimulatory and antitumor activities Upon administration of the pooled mutant KRAS-targeted long peptide vaccine, the KRAS peptides may stimulate the host immune system to mount a cytotoxic T-cell lymphocyte (CTL)-mediated immune response against KRAS-expressing tumor cells. KRAS, a tumor-associated antigen (TAA) that plays a key role in the RAS/mitogen-activated protein kinase (MAPK) signaling pathway, is overexpressed on a variety of tumor cell types.",
  "synonyms": [
    "KRAS peptide vaccine",
    "pooled mutant KRAS peptide vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pooled-mutant-kras-targeted-long-peptide-vaccine/"
}