prochlorperazine

{
  "id": "MLC-T-ONC-006934",
  "term": "prochlorperazine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics.",
    "The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension."
  ],
  "synonyms": [
    "Compazine",
    "prochlorperazine dimaleate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/prochlorperazine/"
}