rabusertib

{
  "id": "MLC-T-ONC-016337",
  "term": "rabusertib",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "checkpoint kinase 2 inhibitor LY2603618",
    "CHK2 inhibitor LY2603618"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rabusertib/"
}